1. Anti-angiogenesis

“Anti-angiogenesis”  TetraAs(As4O6) inhibits the growth of cancer by blocking the angiogenic switch which leads to tumor expression of pro-angiogenic factors and increased tumor vascularization

  1. Generation of angiogenesis factor
  2. Discharge
  3. Binding to receptor on endothelial cells
  4. Proliferation of endothelial cells
  1. Contorl of extra-celluar materials and migration of endothelial cells
  1. Vascularization
  2. Formation of vascular circle
  3. Stabilization of vascular system
2. Apoptosis

As4O6 induces the apoptosis and the expression of apoptosis-related proteins by significantly suppressing the proliferating cell nuclear antigen.

3. Suppression of NF-KB activity

As4O6 suppress downstream NF-KB-regulated proteins involved in cancer anti-apoptosis, proliferation, invasion and metastasis and NF-KB-mediated cellular responses