“Anti-angiogenesis” TetraAs(As4O6) inhibits the growth of cancer by blocking the angiogenic switch which leads to tumor expression of pro-angiogenic factors and increased tumor vascularization
As4O6 induces the apoptosis and the expression of apoptosis-related proteins by significantly suppressing the proliferating cell nuclear antigen.
3. Suppression of NF-KB activity
As4O6 suppress downstream NF-KB-regulated proteins involved in cancer anti-apoptosis, proliferation, invasion and metastasis and NF-KB-mediated cellular responses